Wednesday, 26 February 2014

Our unrealistic attitudes about death, through a doctor’s eyes



By Craig Bowron, Published: February 17, 2012 on The Washington Post.

I know where this phone call is going. I’m on the hospital wards, and a physician in the emergency room downstairs is talking to me about an elderly patient who needs to be admitted to the hospital. The patient is new to me, but the story is familiar: He has several chronic conditions — heart failure, weak kidneys, anemia, Parkinson’s and mild dementia — all tentatively held in check by a fistful of medications. He has been falling more frequently, and his appetite has fallen off, too. Now a stroke threatens to topple this house of cards.

The ER physician and I talk briefly about what can be done. The stroke has driven the patient’s blood pressure through the roof, aggravating his heart failure, which in turn is threatening his fragile kidneys. The stroke is bad enough that, given his disabilities related to his Parkinson’s, he will probably never walk again. In elderly patients with a web of medical conditions, the potential complications of any therapy are often large and the benefits small. It’s a medical checkmate; all moves end in abdication.

Read the rest here.

Thursday, 20 February 2014

Shoulder.co.uk


Shoulderdoc - Patient information and professional educational material on shoulder and elbow problems

Len Funk established ShoulderDoc.co.uk in 2002. Since then it has become the most popular Shoulder & Elbow information website on the internet, receiving over 150,000 hits per day!.

ShoulderDoc  started off as a simple site to provide our own patients with information and guidance that was not easily available elsewhere. We have tried to make the site as user-friendly as possible and content is added almost daily.

All articles added to the website including medical content are written by medical professionals and peer-reviewed by Prof. Lennard Funk. Wherever possible the reference sources are mentioned and hyper-linked. Sources for reference material include medical textbooks, clinical and scientific journals and our own clinical audits.

Our mission is:
  • To be the one of the best resources of shoulder and elbow information.
  • To educate and partner our patients in making decisions at every stage.
  • To ensure that our clinical practice is of  the highest integrity and evidence based.
  • To promote and provide teaching, research and innovation.

Physical Therapy EBP videos, advices, ideas - Physical Therapy Nation



Physical Therapy Nation is platform which facilitates the sharing of evidence based information worldwide among both physical therapy students and active clinicians. PT Nation is also a completely free evidence based video database of over 1,000 internally filmed videos. The video library is free to all student PTs and licensed clinicians. It includes instruction covering manual therapy techniques, examinations, special tests, and many specialty areas like vestibular therapy and orthotic casting and fabrication.

The goal of Physical Therapy Nation is to promote, enhance, and move the profession of PT forward by providing a free video focused resource to all clinicians.


Wednesday, 19 February 2014

Tuesday, 18 February 2014

European Multicenter Study about Spinal Cord Injury



EMSC is an internationally recognized and scientifically successful clinical spinal cord injury network.

Aim: Establishing a multi-center basis for future therapeutic interventions in human spinal cord injury.

Nogo antibody study for spinal cord injury recovery



Project 

Nogo is a protein that only occurs in the central nervous system and prevents nerve regeneration. However, anti-Nogo antibodies make damaged nerve fibres grow.

As part of a worldwide study with pharmaceutical company Novartis, we are currently running tests involving paralysed patients.

Researchers 
N.N. 

FAQ on the Nogo antibody study

What is the Nogo antibody study actually about?

The study aims to prove that Nogo antibodies can make damaged nerve fibres regrow in humans (not just animals) and that this growth can lead to partial improvement of the body's functions and sensitivity. At present, this medication is in an early clinical stage and is undergoing pharmacokinetic tests and tests for tolerance (to determine possible side-effects). Treatment involves injecting Nogo antibodies into the spinal fluid and must be administered within 14 days of the accident. The Nogo antibody study is being conducted in Switzerland in close cooperation between the Paraplegic Centre at Balgrist University Hospital, various trauma centres and Novartis. We are the testing centre for Switzerland - our clinic is the only one in Switzerland offering this treatment at present.

The Nogo antibody study is giving people hope. Can people in the acute stage of spinal paralysis be helped?

Unfortunately, we will currently have to disappoint anyone who is hoping that this may be a cure. At best, we can expect improvements to movement and sensitivity, which will be useful to paralysed people in their day-to-day lives. For example, a tetraplegic may require less assistance or a paraplegic may regain some sensitivity in paralysed body parts. For the time being, the aim of the Nogo antibody study is to test tolerance in humans and check for any side-effects.

Read the rest here.

Balgrist Spinal Cord Injury Center


ETH Zürich

The Spinal Cord Injury Center at the Balgrist University Hospital is an internationally acknowledged rehabilitation center for patients with spinal cord injury (SCI). It comprises a 40 beds clinical unit and is linked excellently with its research facilities, located in the same building.

The focus of our research is the optimization and further development of existing and new interventions for patients with a spinal cord injury (SCI). Patients with SCI report that their priorities for recovery are bladder and bowel management and hand function in patients with high cervical lesions. Both also the recovery of walking function is highly appreciated. Indeed, besides other interests, these topics are covered by our research groups.

Our research is in general focussed on how the central nervous system reacts to the condition after SCI by investigating plastic changes in the sensory – motor and autonomic nervous system within the brain and spinal cord. Furthermore, we are interested how training interventions could exploit this plasticity to improve the functional outcome and independence of the patient. One focus of our lab is, in collaboration with the SMS Lab (ETHZ) and Hocoma AG, to develop and/or improve rehabilitation robotics for the upper and lower extremity and investigate their effect on the functional independence of our patients. We are also involved in clinical studies investigating safety of the anti-NOGO antibody, which should increase plasticity and regeneration of the damaged spinal cord (more information).

Improvement in training strategies can only be performed if adequate and sensitive outcome measures are available. Therefore, we develop and test the ability of neurological, neuro-physiological and functional outcome measures to detect small changes in our patients, which is required for clinical studies, but also the relevance of these changes for the functional status of the patient. Indeed, we are the leading center in an international collaboration evaluating outcome measures (www.emsci.org).

Monday, 17 February 2014

A microscope for your videos



Fun gait analysis by Kinovea!

Kinovea is a video player for all sport enthusiasts. Slow down, study and comment the technique of your athletes or of yourself. It is 100% free and open source.

Sunday, 16 February 2014

Stressed mothers 'transmit stress patterns to offspring'


Pregnant lady sitting with a laptop looking stressed

New research suggests that infants born to mothers who have been through stressful life events may experience changes at birth that impact their emotional behavior well into adulthood. This is according to a study published in the journal Biological Psychiatry.

Researchers from the University of Haifa in Israel say that previous research conducted in both humans and animals has shown that females who are exposed to stress even before they conceive can have have an impact on offspring.

The 5 stages of loss and grief


The 5 Stages of Loss and Grief

By JULIE AXELROD @ http://psychcentral.com/

The stages of mourning and grief are universal and are experienced by people from all walks of life. Mourning occurs in response to an individual’s own terminal illness or to the death of a valued being, human or animal. There are five stages of normal grief that were first proposed by Elisabeth Kübler-Ross in her 1969 book “On Death and Dying.”

In our bereavement, we spend different lengths of time working through each step and express each stage more or less intensely. The five stages do not necessarily occur in order. We often move between stages before achieving a more peaceful acceptance of death. Many of us are not afforded the luxury of time required to achieve this final stage of grief.

The death of your loved one might inspire you to evaluate your own feelings of mortality. Throughout each stage, a common thread of hope emerges: As long as there is life, there is hope. As long as there is hope, there is life.

Many people do not experience the stages in the order listed below, which is okay. The key to understanding the stages is not to feel like you must go through every one of them, in precise order. Instead, it’s more helpful to look at them as guides in the grieving process — it helps you understand and put into context where you are.

1. Denial and Isolation
The first reaction to learning of terminal illness or death of a cherished loved one is to deny the reality of the situation. It is a normal reaction to rationalize overwhelming emotions. It is a defense mechanism that buffers the immediate shock. We block out the words and hide from the facts. This is a temporary response that carries us through the first wave of pain.

2. Anger
As the masking effects of denial and isolation begin to wear, reality and its pain re-emerge. We are not ready. The intense emotion is deflected from our vulnerable core, redirected and expressed instead as anger. The anger may be aimed at inanimate objects, complete strangers, friends or family. Anger may be directed at our dying or deceased loved one. Rationally, we know the person is not to be blamed. Emotionally, however, we may resent the person for causing us pain or for leaving us. We feel guilty for being angry, and this makes us more angry.

Remember, grieving is a personal process that has no time limit, nor one “right” way to do it.

The doctor who diagnosed the illness and was unable to cure the disease might become a convenient target. Health professionals deal with death and dying every day. That does not make them immune to the suffering of their patients or to those who grieve for them.

Do not hesitate to ask your doctor to give you extra time or to explain just once more the details of your loved one’s illness. Arrange a special appointment or ask that he telephone you at the end of his day. Ask for clear answers to your questions regarding medical diagnosis and treatment. Understand the options available to you. Take your time.

3. Bargaining
The normal reaction to feelings of helplessness and vulnerability is often a need to regain control:

If only we had sought medical attention sooner…
If only we got a second opinion from another doctor…
If only we had tried to be a better person toward them…

Secretly, we may make a deal with God or our higher power in an attempt to postpone the inevitable. This is a weaker line of defense to protect us from the painful reality.

4. Depression
Two types of depression are associated with mourning. The first one is a reaction to practical implications relating to the loss. Sadness and regret predominate this type of depression. We worry about the costs and burial. We worry that, in our grief, we have spent less time with others that depend on us. This phase may be eased by simple clarification and reassurance. We may need a bit of helpful cooperation and a few kind words. The second type of depression is more subtle and, in a sense, perhaps more private. It is our quiet preparation to separate and to bid our loved one farewell. Sometimes all we really need is a hug.

5. Acceptance
Reaching this stage of mourning is a gift not afforded to everyone. Death may be sudden and unexpected or we may never see beyond our anger or denial. It is not necessarily a mark of bravery to resist the inevitable and to deny ourselves the opportunity to make our peace. This phase is marked by withdrawal and calm. This is not a period of happiness and must be distinguished from depression.

Loved ones that are terminally ill or aging appear to go through a final period of withdrawal. This is by no means a suggestion that they are aware of their own impending death or such, only that physical decline may be sufficient to produce a similar response. Their behavior implies that it is natural to reach a stage at which social interaction is limited. The dignity and grace shown by our dying loved ones may well be their last gift to us.

Coping with loss is a ultimately a deeply personal and singular experience — nobody can help you go through it more easily or understand all the emotions that you’re going through. But others can be there for you and help comfort you through this process. The best thing you can do is to allow yourself to feel the grief as it comes over you. Resisting it only will prolong the natural process of healing.

Saturday, 15 February 2014

ConsumerLab.com - independent test results



ConsumerLab.com, LLC ("CL") is the leading provider of independent test results and information to help consumers and healthcare professionals identify the best quality health and nutrition products. It publishes results of its tests in comprehensive reports at www.consumerlab.com. CL also conducts an annual Survey of Vitamin & Supplement Users. CL’s research is cited frequently by the media, in books, and at professional meetings. In addition to the products it selects to review, CL enables companies of all sizes to have their products quality tested for potential inclusion in its list of Approved Quality products and bear the CL Seal. Since its founding in 1999, CL has tested more than 3,400 products, representing over 450 different brands and nearly every type of popular supplement for adults, children, and pets. 

Drug information online


Drugs.com

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Data sources include Micromedex™ (updated Dec 30th, 2013), Cerner Multum™ (updated Jan 17th, 2014), Wolters Kluwer™ (updated Jan 9th, 2014) and others. To view content sources and attributions, refer to our editorial policy.

Copyright © 2000-2014 Drugs.com. All rights reserved.

Six pack exercises



A very nice link with different exercises for abs.

Pathophysiology of the endocrine system




A wonderful link on Pathophysiology of the endocrine system by Colorado State University.

The pages in this book are initially categorized based on scientific discipline (e.g. Endocrine Pathophysiology, Medical Virology, etc.), but there are many links between disciplines (e.g. links between pages describing the physiology of the stomach in the Digestive Pathophysiology section and pages in the Endocrine Pathophysiology section describing gastric hormones.

How Do You Want to Grow?



Reviewed for medical accuracy by: Kestrson S., M.D.
Added to knowledge base: 10/16/08

Growth hormone supplementation has been widely publicized lately due to recent allegations against Jason Grimsley and David Segui of Major League Baseball fame.  People choose to take the supplement for a promise of augmented athletic performance or to turn back the clock on life, without chance of detection by governing agencies.  Before jumping on the bandwagon, you should know what growth hormone is and what its effects are.

What is Growth Hormone?

The polypeptide human growth hormone, hGH, is one of the most important naturally occurring hormones for normal growth to adult size.  It is normally secreted in a pulsatile fashion 6-12 times per day, meaning concentrations fluctuate throughout the day.  Growth hormone secretion peaks during puberty and decreases with age.  Secretion is increased by sleep, stress, starvation, puberty, exercise, hypoglycemia (low blood sugar), and other hormones (ie growth hormone releasing hormone).   

hGH secretion is inhibited by somatostatin (from the hypothalamus), somatomedins (hormones released by the hGH target organs in response to a rise in hGH), obesity, hyperglycemia (high blood sugar) and pregnancy.  It is important to understand that like many other hormone systems in the body, hGH and GHRH inhibit their own secretion as part of a negative feedback system.

What is the effect of Growth Hormone?

hGH is taken up by skeletal muscle and has many effects.  It acts directly to decrease glucose uptake into cells, increase hepatic gluconeogenisis, increase lipolysis (fat release from adipose cells), increase protein synthesis in muscle cells, increase lean body mass and increase release of insulin like growth factor (IGF-1) from the liver and locally in skeletal muscle.  IGF-1 increases bone length in children, increases protein synthesis in muscle and increases lean body mass.  Both growth hormone and IGF-1 are anabolic, non-androgenic compounds.  This means that it promotes protein synthesis without stimulating male secondary sex characteristics.

Are there diseases of Growth Hormone secretion?
Yes.  A deficiency in hGH can result in failure to grow and mild obesity.  Currently the FDA has approved growth hormone therapy in the treatment of childhood growth deficiencies and wasting diseases such as AIDS. 

There are also diseases of excess growth hormone secretion.  Excess hGH before puberty can cause gigantism and after puberty causes an increase in bone growth, organ size and glucose intolerance.

How can I increase my levels of hGH?
As already mentioned, exercise can naturally increase growth hormone secretion.  Research has shown that exercise counteracts the negative feedback mechanisms of GHRH and hGH allowing levels to rise unchecked by this feedback system.  Research has also shown that repeated exercise sessions led to an increase in hGH after each session and over a 24 hour period.  Results suggest that load and frequency of the resistance exercise are important determinants of hGH concentration while length of the workout is not. 

Over the short term, endurance exercise also increases growth hormone release.  Significant increases in plasma growth hormone was noted after 10 minutes of exercise above the lactic acid threshold (ie high intensity).  Multiple exercise sessions further increased the amount of growth hormone released per pulse rather than leading to feedback inhibition.  However, in response to chronic endurance exercise (greater than 3 weeks), some studies found a decreased growth hormone response to additional exercise bouts.  This suggests that the hGH response to endurance exercise is adaptive and may plateau with time.

Read the rest. It has nice information on GH supplements.

Cheetah's speed secrets are revealed



A sprinting cheetah is like "a rear-wheel-drive car," say scientists.

Japanese researchers mapped the muscle fibres of the big cat known to accelerate to record-breaking speeds.

By comparing the cheetah's muscles with those of a domestic cat and dog, the team identified the special propulsion power of its hindlimb muscles.

Read the rest here on BBC. Also interesting facts on cheetah's myology and physiology here.

Want to go more deep? Read "Distribution of muscle fibers in skeletal muscles of the cheetah (Acinonyx jubatus), Megumi et al, on http://www.sciencedirect.com/:

Abstract

We examine the muscle fiber population of skeletal muscles from whole body in the cheetah (Acinonyx jubatus). In the present experiments, we showed the characteristics of fiber composition in the cheetah by comparative studies among the cheetah, domestic cat, and the beagle dog. Fiber population was determined on muscle fibers stained with monoclonal antibody to each myosin heavy chain isoform. Histochemical analysis demonstrated that many muscles in the cheetah and domestic cat had a low percentage of Type I fibers and a high percentage of Type IIx fibers, while those in the beagle dog showed a high percentage of Type IIa. The hindlimb muscles in the cheetah had a higher percentage of Type II (Type IIa + IIx) fiber than the forelimb muscles. This fact suggests that the propulsive role of the hindlimb is greater than the forelimb in the cheetah. The longissimus in the cheetah had a high percentage of Type IIx fibers over a wide range from the thoracic to lumbar parts, while the population of muscle fibers in this muscle was different depending on the parts in the domestic cat and beagle dog. This indicates that the cheetah can produce a strong and quick extension of the spinal column and increase its stiffness during locomotion. Furthermore, we found the notable difference of muscle fiber type population between flexors and extensors of digits in the cheetah. The present experiments show the characteristics of muscle fibers in the cheetah, corresponded to its ability to perform high-speed running.

Athletics - Men's 200m - T44 Final - London 2012 Paralympic Games




GOLD OLIVEIRA Alan Fonteles Cardoso BRA - Brazil
SILVER PISTORIUS Oscar RSA - South Africa
BRONZE LEEPER Blake USA - United States of America

The International Paralympic Committee (IPC) is the global governing body of the Paralympic Movement. The IPC organizes the Summer and Winter Paralympic Games, and serves as the International Federation for nine sports, for which it supervises and co-ordinates the World Championships and other competitions. The IPC is committed to enabling Paralympic athletes to achieve sporting excellence and to develop sport opportunities for all persons with a disability from the beginner to elite level. In addition, the IPC aims to promote the Paralympic values, which include courage, determination, inspiration and equality.

For further information, please visit http://www.paralympic.org.

Clinical guidelines for delirium



Delirium (sometimes called 'acute confusional state') is a common clinical syndrome characterised by disturbed consciousness, cognitive function or perception, which has an acute onset and fluctuating course. It usually develops over 1–2 days. It is a serious condition that is associated with poor outcomes. However, it can be prevented and treated if dealt with urgently. A person may already have delirium when they present to hospital or long-term care or it may develop during a hospital admission or residential stay in long-term care. Delirium can be hypoactive or hyperactive but some people show signs of both (mixed). People with hyperactive delirium have heightened arousal and can be restless, agitated and aggressive. People with hypoactive delirium become withdrawn, quiet and sleepy. Hypoactive and mixed delirium can be more difficult to recognise.

Guidelines for diagnosis, prevention and management of delirium here.

Wednesday, 12 February 2014

Scientists create first map of brain ‘scaffold’


This is a graphical representation of the white matter scaffold discussed in the article.

By Suzanne Wu

February 11, 2014

For the first time, neuroscientists have systematically identified the white matter “scaffold” of the human brain, the critical communications network that supports brain function.

Their work, published Feb. 11 in the open-source journal Frontiers in Human Neuroscience, has major implications for understanding brain injury and disease. By detailing the connections that have the greatest influence over all other connections, the researchers offer not only a landmark first map of core white matter pathways, but also show which connections may be most vulnerable to damage.

- Read the rest here.

Tuesday, 11 February 2014

Using stem cells from hip replacements to help treat ageing adults




The tissue normally discarded during routine hip replacements could be a rich new source of adult stem cells for use in regenerative medicine, UNSW-led research has found.

With tens of thousands of hip replacement surgeries performed each year, this tissue could have “profound implications” in clinical use, the scientists say.

“In hip replacement surgery, the femoral head and part of the neck are resected to accommodate the neck of the implant,” explains study leader Professor Melissa Knothe Tate, the Paul M Trainor Chair in Biomedical Engineering at UNSW.

“Typically this tissue is discarded, yet it may provide an untapped source of autologous stem cells for ageing adults who were born a generation too early to benefit from banking of tissues like umbilical cord blood at birth.”

The study, published in the latest issue of STEM CELLS Translational Medicine, was led by the UNSW Graduate School of Biomedical Engineering and involved orthopaedic surgeon Dr Ulf Knothe of the Cleveland Clinic in Cleveland, scientists from Ludwig Maximilians University in Munich and Case Western Reserve University in Cleveland.

The researchers wanted to determine the feasibility of using the patient’s own tissue removed during routine joint replacement to potentially heal and/or repair failing organs and to treat diseases.

The team collected periosteum derived stem cells (PDCs) from patients with rheumatoid arthritis or osteoarthritis, ranging in age from 30 to 72 years, who had undergone joint replacements. They compared them with commercial bone marrow stem cells derived from prenatal donors in patients up to 72-years-old.

Based on the results, the PDCs exhibited “remarkable similarities” to the bone marrow cells cultured under identical laboratory conditions. They also showed “no significant differences” in their ability to differentiate into other cells due to the donor’s age or disease state,” Professor Knothe Tate and her team said in their paper.

“The use of periosteum tissue that is discarded with the femoral neck in replacing the hip is highly novel, as it represents an unprecedented and to date unstudied source of stem cells from rheumatoid arthritis or osteoarthritis patients,” they said.

Dr Ulf Knothe, the leading clinician on the study, concluded: “Use of stem cells from periosteum may open up unprecedented opportunities for the treatment of disease and tissue/organ failure in a population of osteoarthritic patients born around four decades too early to bank their own cord tissue or blood.”

The full article, “Arthritic periosteal tissue from joint replacement surgery: A novel, autologous source of stem cells,” will be available online after the embargo lifts: http://www.stemcellstm.com.

Media contact for Professor Knothe Tate: Fiona MacDonald, UNSW Media Office, +61 (0) 403 664 438, fionajmacdonald@gmail.com. Images available plus more on Professor Knothe Tate.

Sunday, 9 February 2014

Joint Play Techniques In Assessment And Therapy For Upper And Lower Extremities



Beautiful and very detailed website to provide both students of physiotherapy and physiotherapists alike, with an interactive online information source for manual mobilization of the extremities.

NIH Senior Health



"This website will open the valuable resources of the NIH to great numbers of people over 60 who use the Internet to learn more about their health and aging."

Richard J. Hodes, M.D.
Director, National Institute on Aging

Saturday, 8 February 2014

Osteoporosis and bone physiology


backscattered electron image of bone

This is an amazing educational site for physicians and patients. Site maintained by Susan Ott, MD Professor of Medicine University of Washington.

Tuesday, 4 February 2014

The Future of Prosthetics: Mind-Bending Robotic Arms



Researchers have shown that patients paralyzed from the neck down can move robotic arms with their minds, according to a new report in the journal Nature that documents two cases involving brain-stem stroke victims. Margaret Warner discusses the hopes for the technology with Dr. Leigh Hochberg of Massachusetts General Hospital.

Sunday, 2 February 2014

Sprinting simply cannot be beat!


Sprinting: The Purest, Most Powerful Physique-Shaper In An Athlete's Arsenal: Part I

"When it comes to cutting you up and promoting a nutrient-partitioning milieu conducive to building and maintaining a lean, muscular physique, sprinting simply cannot be beat. A simple look at competitive athletics demonstrates this pretty clearly".

Amazed? Read the rest here.

Saturday, 1 February 2014

Neuroplasticity


An animation created in Maya that visualizes the plasticity of the motor cortex when one learns a new skill.